| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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NSI-189 phosphate powder is neurogenic and nootropic research agent that was developed from nicotinamide and pyrazine. Randomized controlled trials have shown that it stimulates neurogenesis or neuronal cell production in the brain. In animal studies, it has also been shown to increase the volume of hippocampus by 20% thereby reversing behavioral symptoms of depression. Such studies have shown that it may be an effective treatment for depression. It is also thought to be a promising treatment for other condition including post-traumatic stress disorder (PTSD), Alzheimer's disease and age-related cognitive problems.
1.Enhance cognition and memory formation NSI-189 phosphate powder
2.Anxiolytic properties NSI-189 phosphate powder
3.Anti-depressive effect NSI-189 phosphate powder
4.Treatment of Alzheimer's and Parkinson's disease NSI-189 phosphate powder
5.Increase coordination NSI-189 phosphate powder
6.Improves mood NSI-189 phosphate powder
7.Help fight fatigue NSI-189 phosphate powder
8.Prevent oxidation within the brain NSI-189 phosphate powder
9.Treat alcohol related brain damage NSI-189 phosphate powder
NSI-189 successfully completed a phase I clinical trial for MDD in 2011, where it was administered to 41 healthy volunteers. A phase Ib clinical trial for treating MDD in 24 patients started in 2012 and completed in July 2014, with results published in December 2015. Neuralstem is now preparing to initiate phase II clinical studies for MDD in the first quarter of 2016, with results expected in the second half of 2017. In the two clinical studies conducted thus far, NSI-189 has shown statistically significant effectiveness in reducing depressive symptoms, has been found to be safe and well-tolerated (with no major adverse effects observed), and has been found to improve cognitive deficits in depressed patients. In addition to MDD, Neuralstem intends to pursue clinical development of NSI-189 for a variety of other neurological conditions, including traumatic brain injury, Alzheimer's disease, post-traumatic stress disorder, stroke, and natural cognitive and memory decline in aging.
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