| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| Product Name: | Procain-e Hydrochloride |
| CAS No: | 51-05-8 |
| Melting point: | 155-156 °C(lit.) |
| Boiling point: | 195-196°C 17mm |
| Place of Origin: | China |
| Type: | Pharmaceutical intermediates |
| Appearance: | Crytal |
| Color | Colorless to white |
| Purity: | 99.9% |
| Packing: | 25kg/Cartoon Box |
| Application: | Local Anesthetic |
| Storage: | Sealed in dry,2-8°C |
| Sample: | available |
| Shelf life: | 2 years |
Procaine HCl is a short-acting ester local anesthetic and one of the oldest spinal anesthetics, having originally replaced as the drug of choice for spinal anesthesia in the early 20th century. Procaine itself was then replaced by lidocaine, but with concerns about lidocaine and transient neurologic symptoms (TNS), procaine has recently been reexamined as an alternative fast-acting local anesthetic.
Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of
intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade
name Novocain, in some regions procaine is referred to generically It acts mainly by being a sodium
channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-
inflammatory, perfusion enhancing, and mood enhancing effects.
Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local
infiltration and peripheral nerve block techniques.
Application of procaine leads to the depression of neuronal activity. The depression causes the nervous
system to become hypersensitive producing restlessness and shaking, leading to minor to severe
convulsions. Studies on animals have shown the use of procaine led to the increase of dopamine and
serotonin levels in the brain.Other issues may occur because of varying individual tolerance to procaine
dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which
may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium
leading to cardiac arrest.
Procaine can also cause allergic reactions causing the individuals to have problems with breathing,
rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to
its metabolite PABA. About one in 3000 people have an atypical form of pseudocholinesterase,[citation
needed] which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period
of high levels of the anesthetic in the blood and increased toxicity.
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