| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| Product name | Nystatin |
| Cas number | 1400-61-9 |
| Apperance | Yellow powder |
| MF | C47H75NO17 |
| EINECS | 215-749-0 |
What is Nystatin?
Nystatin is a polyene antifungal drug to which many molds and yeast infections are sensitive, including Candida.
Cutaneous, vaginal, mucosal and esophageal Candida infections usually respond well to treatment with nystatin.
Like amphotericin B and natamycin, nystatin binds to ergosterol, a major component of the fungal cell membrane. When present in sufficient concentrations, it forms pores in the membrane that lead to K+ leakage and death of the fungus.
Nystatin is a polyene antibiotic. The first anti-mold antibiotic was discovered in 1950 when Streptomyces noursei, a soil microbe, was found to secrete an anti-mold substance. Nystatin has conjugated polyene macrolide structure, which can inhibit the activity of fungi and dermococcus, but has no inhibitory effect on bacteria
Nystatin is an antifungal medication that belongs to the polyene class of drugs. It is available in various forms, including oral tablets, topical creams, and powders. Nystatin works by binding to the fungal cell membrane, causing it to become permeable and leading to cell death. It is primarily used to treat fungal infections, particularly those caused by Candida species. Nystatin is effective against a wide range of fungi and is commonly used for conditions such as oral thrush, diaper rash, and vaginal yeast infections.
1). Nystatin is often used as prophylaxis in patients who are at risk for fungal infections.
2). It is prescribed in units, with doses varying from 100,000 (for oral infections) to 1 million (for intestinal ones). As it is not absorbed from the gut, it is safe for oral use and does not have problems of drug interactions.
3). It is also used in cellular biology as an inhibitor of the lipid raft-caveolae endocytosis pathway on mammalian cells, at concentrations around 3 µg/mL.
4). In certain cases, nystatin has been used to prevent the spread of mold on objects such as works of art. For example, it was applied to wood panel paintings damaged as a result of the Arno River Flood of 1966 in Florence, Italy.
5). Nystatin is also used as a tool by scientists performing "perforated" patch-clamp electrophysiologic recordings of cells. When loaded in the recording pipette, it allows for measurement of electrical currents without washing out the intracellular contents, because it forms pores in the cell membrane that are permeable to only monovalent ions.
Nystatin is used in various forms and for different applications, depending on the site and severity of the fungal infection. The oral formulation of nystatin, available as tablets or suspensions, is used to treat oral thrush or gastrointestinal candidiasis. It is usually prescribed for individuals with weakened immune systems or those who have been treated with antibiotics that have disrupted the natural balance of microorganisms in the body.
Topical nystatin comes in the form of creams, ointments, or powders and is primarily used to treat skin and mucous membrane fungal infections. It is commonly applied to areas affected by diaper rash, skin folds, athlete's foot, and vaginal yeast infections. The topical application allows for a localized treatment, targeting the specific area of infection.
Overall, nystatin is a potent antifungal medication that provides relief from various fungal infections by targeting and eliminating the causative fungi. It is widely used and considered safe and effective when used as prescribed by a healthcare professional.
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