| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| Items | Standards | Results | |
| Appearance | White solid powder | Complies | |
| Identification | By IR | Complies | |
| By HPLC | Complies | ||
| Solubility | Practically insolubale in water and ethanol,very soluble in dimethyl sulfoxide | Complies | |
| Water Content | ≤ 0.50% | 0.18% | |
| Heavy Metal | ≤ 20ppm | Complies | |
| Residue on Ignition | ≤ 0.10% | 0.05% | |
| Residual Solvents | Ethanol: ≤5000ppm | 300ppm | |
| Meth anol: ≤3000ppm | ND | ||
| Dimethyl sulfoxide: ≤5000ppm | ND | ||
| N,N-Dimethyl formamide: ≤880ppm | 820ppm | ||
| Acetic acid: ≤5000ppm | ND | ||
| Methyl tert-tutyl ether≤5000ppm | ND | ||
| Related Substances | Any single impurity: ≤0.10% | 0.02% | |
| Total Impurities: ≤1.00% | 0.10% | ||
| Assay (HPLC basis on drying) |
98.0%~102.0% | 99.92% | |
| Reference Standard | In-house Standard | ||
| Conclusion | The product complied to In-house standard. | ||
| Storage | Preserve in tight,light-resistant containers in a | ||
Pomalidomide is an orally bioavailable derivative of thalidomide with potential immunomodulating, antiangiogenic and antineoplastic activities. Although its exact mechanism of action has yet to be fully elucidated, pomalidomide appears to inhibit TNF-alpha production, enhance the activity of T cells and natural killer (NK) cells and enhance antibody-dependent cellular cytotoxicity (ADCC). In addition, pomalidomide may inhibit tumor angiogenesis, promote cell cycle arrest in susceptible tumor cell populations, and stimulate erythropoeisis.
Uridine 5-Mophosphate Disodium are produced through the hydrolytic reaction from Ribonucleic acid(RNA) as raw material by enzymatic catalysis to form four kinds of nucleotides 5- 'AMP (adenosine-5'-monophosphate), 5'-GMP•2Na(guanosine-5'-monophosphate, disodium salt), 5'-CMP(cytidine-5'-monophosphate)-, 5'-UMP•2Na (uridine- 5'-monophosphate,Disodium salt) .By the chromatographic isolation, four kinds of separated 5'-nucleotide products with high purity can be obtained. These products can be widely applied in medicine, reagent, fine chemical industry, and additive of food fields etc
Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
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