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Icariin is a prenylflavonoid with anti-cancer properties and is studied for its diverse signaling effects observed in vivo. It has been documented to stimulate pathways that induce osteogenesis, decrease inflammation and promote angiogenesis.
Icariin has been shown in vivo to induce mice bone formation through upregulating runt-related transcription factor 2 (Runx2) genes and increasing bone morphogenic protein expression. These prompt osteogenic differentiation and bone development. Also, icariin invokes marrow stromal cell proliferation via increased alkaline phosphatase activity.